Structural and functional hybridization of a biomolecule with another chemical component has been often adopted for design of advanced nanomaterials. Along this line, we have recently developed the cerasome, a liposomal membrane having a ceramic surface, as a novel organic-inorganic hybrid material. Owing to its extremely high morphological stability as compared with the conventional liposomes, the cerasome performs as an excellent biomembrane model to construct artificial multi-cellular systems. We have also revealed that the cationic cerasome can be used as an infusible and cell-friendly gene carrier. In order to break fresh ground for the cerasomes as the nanohybrid materials, we have prepared the metallosome, a metal-coated liposome, by employing electroless plating technique toward the cerasomes. In addition, functionalization of the cerasome surface by introducing titania or hydroxyapatite has been achieved.